杭州沈氏微化工事业部,专注于使用微反应技术从事连续工艺开发。目前有研发团队20人,多人曾供职于知名外企和制药企业。总部实验室约400平米,同时在上海有机所及中国计量大学建有实验室。
我们实行“一站式”项目开发服务:提供微反应器工艺研发、工业化系统集成、工业化“交钥匙”工厂全流程技术服务。
集成式微通道反应器:由换热单元、反应单元组成,通过扩散焊接一体成型,无任何除母材之外的其他成分。
高换热效率:换热流道采用微通道结构设计,有效强化传热表面,提升换热效率;整体采用扩散焊接方式加工,无母材之外的任何接触热阻;
高传质高收率:反应流道应用切割阻挡原理,采用微通道结构设计,大幅提升传质效率;
高承压:扩散焊接使不同单元间融为一体,承压可达20MPa以上;微通道结构方式使流道内部在高压情况下受力大幅降低,提高使用压力;
使用安全:高通量、低滞留量、强换热,大幅因降低反应过程产生的安全问题;
连续可控:集成式方案设计、温度流量控制调节精度高、可实现大通量连续化生产。
沈氏专利结构
沈氏微反应器单元结构
常用反应装置的对比
类别 | 单位传热面积 S/V(m²/m³) | 传热系数 U(W/m²`k) | 总传热系数U*(S/V)kW/m³K |
夹套反应釜 | 2.5 | 400 | 1 |
内盘管反应釜 | 10 | 1000 | 10 |
金属列管换热器 (Water/Water; 1m/s) | 400 | 500 | 200 |
金属板式换热器 (4mm;Water/Water;1m/s) | 800 | 1563 | 1250 |
玻璃功能模块 (Water/Water; 0.7m/s) | 2500 | 680 | 1700 |
沈氏不锈钢反应板 (Water/Water; 0.7m/s) | 5900 | 1500 | 8850 |
沈氏为客户提供微反应器系列产品,从实验室开发到工业化大生产无缝对接。
反应器类型 | 产品外观尺寸 | 滞留量 | 年通量 |
SWR | 70*55mm | 0.7mL | 8-50吨/年
|
WR1 | 156*130mm | 8.2mL
| 50-250吨/年
|
WR2 | 210*205mm | 23mL
| 200-1500吨/年
|
WR3 | 400*370mm | 130mL
| 1000-3000吨/年
|
WR4 | 730*680mm | 500mL
| 2000-6000吨/年 |
微反应装置及系统:
实验室反应装置
微化工系统--反应模块产品展示
微化工系统--管式反应器
连续流微反应装置
Shenshi's microreactor and its application
Hangzhou Shenshi Micro-Chemical Division focuses on continuous process development using micro-reaction technology. There are currently 20 R & D teams, many of whom have worked in well-known foreign companies and pharmaceutical companies. The headquarters laboratory is about 400 square meters, and has laboratories in Shanghai Organic Institute and China Jiliang University.
We implement a "one-stop" project development service: provide micro-reactor process development, industrialized system integration, and industrialized "turnkey" factory full-process technical services.
Integrated microchannel reactor: It is composed of heat exchange unit and reaction unit, and is integrally formed by diffusion welding without any other components except the base material.
High heat exchange efficiency: The heat transfer runner adopts micro-channel structure design, which effectively strengthens the heat transfer surface and improves the heat exchange efficiency; the whole is processed by diffusion welding without any contact thermal resistance except the base material;
High mass transfer and high yield: The reaction flow channel uses the cutting blocking principle and adopts a micro-channel structure design to greatly improve the mass transfer efficiency;
High pressure-bearing: Diffusion welding integrates different units, and the pressure-bearing can reach more than 20MPa; the micro-channel structure makes the internal force of the flow channel greatly reduced under high-pressure conditions, increasing the use pressure
Safety in use: high flux, low retention, and strong heat exchange, greatly reduce the safety problems caused by the reaction process;
Continuously controllable: integrated scheme design, high accuracy of temperature and flow control, and large-volume continuous production.
Shenshi patent structure
Shenshi micro-reaction unit structure
Comparison of common reaction devices
Category | Unit heat transfer area S/V(m²/m³) | Heat transfer coefficient U(W/m²`k) | Total heat transfer coefficient U*(S/V)kW/m³K |
Jacketed reactor | 2.5 | 400 | 1 |
Inner coil reactor | 10 | 1000 | 10 |
Metal tube heat exchanger (Water/Water; 1m/s) | 400 | 500 | 200 |
Metal plate heat exchanger (4mm;Water/Water;1m/s) | 800 | 1563 | 1250 |
Glass function module (Water/Water; 0.7m/s) | 2500 | 680 | 1700 |
Shenshi stainless steel reaction plate (Water/Water; 0.7m/s) | 5900 | 1500 | 8850 |
Shenshi provides customers with a series of micro-reactor products, seamlessly docking from laboratory development to industrial production.
Reactor type | Product size | Retention volume | Annual flux |
SWR | 70*55mm | 0.7mL | 8-50 Tons/year
|
WR1 | 156*130mm | 8.2mL
| 50-250 Tons/year |
WR2 | 210*205mm | 23mL
| 200-1500 Tons/year
|
WR3 | 400*370mm | 130mL
| 1000-3000 Tons/year
|
WR4 | 730*680mm | 500mL
| 2000-6000 Tons/year |
Micro-reaction device and system:
Laboratory reaction device
Reaction Module Product Display
Tubular Reactor
Continuous flow micro-reaction device